Publications
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Model-based analysis of a twin-screw wet granulation system for continuous solid dosage manufacturing Ghent University
Analysing drying unit performance in a continuous pharmaceutical manufacturing line by means of mass-energy balances Ghent University
Predictive, Risk-based Flowability Modelling of Pharmaceutical Powders for Continuous Manufacturing KU Leuven
Over the last decade, the pharmaceutical industry has been transitioning from batch to continuous processing in the interest of process intensification. Continuous manufacturing requires a consistent flow of powder through the tablet production line. This PhD focuses on two challenges related to powder flow: arching and triboelectrification. Two analytical techniques were developed to improve powder characterization to predict the occurrence of ...
Continuous graded Gyroid cellular structures fabricated by selective laser melting: Design, manufacturing and mechanical properties KU Leuven
© 2018 The Authors Functional graded cellular materials (FGCMs) have attracted increasing attentions for their improved properties when compared to uniform cellular structures. In this work, graded Gyroid cellular structures (GCSs) with varying gradient directions were designed and manufactured via selective laser melting (SLM). As a reference, uniform structures were also manufactured. The surface morphology and mechanical response of these ...
Continuous fibre additive manufacturing with in-line impregnated thermoplastic composites Ghent University
Residence Time Distribution characterization in a Continuous Manufacturing tableting line using PCA and PLS-DA modeling KU Leuven
In this work, a new approach to characterize the residence time distribution (RTD) using supervised and unsupervised learning techniques was investigated. The NIR spectral data from the feed frame was used to capture the dynamic response of a continuous tableting line. The data-driven approaches investigated in this study using MPCA and PLS-DA were able to successfully capture the main variation of the step change performed during the RTD ...