Projects
Dental implants with a controlled release functionality KU Leuven
Biodegradable dextran nanogels for the intracellular controlled release of short interfering RNA (siRNA) Ghent University
For in vivo application of therapeutic siRNA, effective delivery is still defined as the major hurdle to overcome. Also, appropriate attention should be paid to optimize the gene silencing effect, both in terms of magnitude and duration. The major focus of this project is therefore the design of dextran nanogels for intracellular controlled release of siRNA.
Novel high-capacity matrix excipients for controlled drug release Ghent University
The aim of this project is to bring the developed UGent proprietary polymer technology of poly(2-oxazoline)s (PAOx) for drug delivery to a next level towards valorization and commercialization with the overarching goal of licensing the polymer technology to pharmaceutical companies bringing it into the regulatory track.
Back behind bars: an empirical study into the experience of prisoners in the recall of semi detention, electronic monitoring and conditional release KU Leuven
The recall of a release modality (such as a conditional release) is a particularly painful experience. The experiences during a release modality can also be very painful and varied: uncertainty, stigmatization, a large number of imposed conditions, constant control and supervision, etc. In addition, a return to prison as a result of a recall can also be experienced as emotional, painful and harmful because of the loss that the recall entails. ...
A holistic decision support tool for optimal lockdown release and further Covid containment Ghent University
An interdisciplinary control tool will be developed to support decision makers during the release of Covid-19 lockdown measures and the subsequent period of virus containment and economic recovery. Survey data on reduced purchase power and social wellbeing will be collected and combined with predictive economic and epidemiological models into an advanced control algorithm allowing for optimal, holistic decisions.
Sustained release of lactic acid from an intravaginal device Ghent University
We seek funding to optimize and clinically validate a lactic acid‐eluting system to combat and prevent recurrent bacterial vaginosis in humans. Under physiological conditions, the vagina harbors a commensal microflora primarily consisting of lactic acid‐producing lactobacilli, thus creating an acidic environment (pH 3.5‐4.5) which provides natural antimicrobial protection to the lower female genital tract. However, during bacterial vaginosis ...
Carnosine release by contracting skeletal muscle Ghent University
Carnosine is present in relatively high concentration in human skeletal muscle. Although carnosine has different functions in other places in the body, it's almost exclusively synthesized in the skeeltal muscle cells. The purpose of this study is to investigate of skeletal muscles can act as storage site and can transport & release carnosine in a controlled way in the interstititum/circulation.
Liposome loaded microbubbles for the ultrasound triggered release of corticosteroids and TNF-α siRNA in the inflamed synovial tissue during rheumatoid arthritis. Ghent University
Rheumatoid arthritis is an inflammatory autoimmune disease characterized by synovial inflammation. In close collaboration with the rheumatoid arthritis group we will evaluate microbubbles and ultrasound for the controlled delivery of corticosteroid and siRNA to inflamed synovial tissue. We hypothesize the use of microbubbles and ultrasound might increase the intraarticular
concentration of corticosteroids and TNF-α siRNA and reduce ...
'Smart' wound dressings for controlled NO-release in chronic wounds KU Leuven
Chronic wounds are nowadays still a serious concern in healthcare and require new and improved treatments. Chronic wounds, such as diabetic foot ulcers, could lead to amputations, which cause an elevated mortality rate, putting them in the same league as some forms of cancer. There already exist treatments such as specific wound dressings for chronic wounds, application of topical growth factors, autologous skin grafts, negative pressure ...