Method for determining responsiveness to an epitope University of Antwerp
Method (100) for determining an immune responsiveness to a query epitope (126) comprising: receiving sequence data (122) comprising TCR sequences of at least a part of a TCR repertoire of a subject; selecting a predictive model (160) generated or trained using a dataset comprising TCR sequences known to bind specifically to a model epitope, said predictive model selected according to a sequence match between the model epitope and query epitope; querying (130) the selected predictive model (160) with the sequence data (122); determining (140) from outputs of the selected predictive model (160) ...