Projects
Genetic risk for frontotemporal lobar degeneration: A genome-wide approach. University of Antwerp
Unraveling the role of VPS13C in lysosomal homeostasis and interorganellar homeostasis using new cellular and in vivo models. KU Leuven
Dementia is one of the main afflictions of today’s society, with Dementia with Lewy Bodies (DLB) representing around 25% of all dementias, only second to Alzheimer’s Disease. DLB, together with Parkinson’s Disease (PD), comprise Lewy Body Diseases (LBD), a group of disorders characterized by the presence of Lewy bodies in the brain. However, the cause for the formation of Lewy bodies, as well as their exact role on the pathogenesis of LBD, is ...
Bilingualism and aging: the case of primary progressive aphasia Vrije Universiteit Brussel
Non-Amyloid Pathological Brain Aging in Late Life Depression KU Leuven
Depression and age-related brain disorders such as dementia are together one of the greatest public health issues of our time. With a rapidly increasing aging population and longer life expectancy, the burden associated with depression in later life will only increase. Understanding the neurobiological mechanisms underlying depression is crucial for limiting the personal and economic impact of the disorder by improving diagnosis and ...
Prediction of conversion to Alzheimer's disease in Down syndrome: a behavioural and neurochemical approach. University of Antwerp
Molecular genetics of early-onset Alzheimer's disease. University of Antwerp
The early microglia–neuron interactions in Alzheimer’s Disease and their modulation by immunotherapy KU Leuven
Alzheimer’s disease (AD) is a chronic neurodegenerative disease and is the most common form of dementia worldwide. We need a better understanding of the initial steps in the disease before brain functions collapse and dementia occurs. The disease cascade is triggered by abnormal accumulation of Amyloid β (Aβ) peptides in the brain, that leads to the formation of peptide oligomers and fibrils and ultimately amyloid plaques. This pathological ...
Xenotransplantation of iPSC derived microglia to decipher the impact of Progranulin in neuroinflammation and neurodegeneration. University of Antwerp
Developing and evaluating innovative interventions to improve Advance Care Planning (ACP): towards a comprehensive multistakeholder model Vrije Universiteit Brussel
between patients, family carers and professionals about preferences
for future end-of-life care. The goal of ACP is to help to ensure that
patients receive care that is consistent with their preferences,
including at times when patients are no longer able to make their own
decisions about care. Despite its importance, the uptake of ACP in
...