Projects
Deciphering the microglia-neuron interactions in human Alzheimer's disease. University of Antwerp
NEURONET - Phase III Hasselt University
Translational investigation of the role of Hsp90 in neurodegenerative proteinopathies using positron emission tomography (PET) KU Leuven
Heat Shock protein-90 (Hsp90) is an ubiquitous "chaperone" protein responsible for (re)folding of client proteins to prevent them from degradation. Hsp90 is expressed at high levels in brain and recent research suggests a role of Hsp90 in neurodegenerative diseases. Positron emission tomography (PET) is a molecular imaging technique that allows in vivo quantification of the body distribution of radioactive tracers. We recently developed PET ...
VIB Grant for Van Den Bosch Lab_Period:2022-01-01-2026-12-31 Flanders Institute for Biotechnology
Gerodent PLUS: primary oral care for home-dwelling elderly Ghent University
The aim of Gerodent PLUS is to promote good oral health and to create the currently absent continuity in the provision of oral care for the rapidly growing group of vulnerable elderly living at home at the level of primary care regions.This goal is pursued through (1) improved interprofessional collaboration between caregivers and (2) improving access to care for frail and care-dependent elderly people who stay at home or in a form of ...
Convergence of tau and TDP-43 in Alzheimer's: towards a multitarget diagnosis KU Leuven
The eye as a window to the brain: tackling neurodegenerative disorders KU Leuven
Alzheimer’s disease (AD) is the leading cause of dementia, affecting 43,8 million people in 2016 and an estimated 130 million by 2050. The pathological changes of AD in the brain occur gradually over 20-30 years before the onset of symptoms and therapies are increasingly aimed at the preclinical stages of the disease. Yet current methods to identify individuals with presymptomatic AD are expensive, invasive and not scalable at a population ...
Speech Processing Techniques for Automatic Detection of Disorders in the Human Brain KU Leuven
Natural Language Processing (NLP) is the branch of artificial intelligence that allows computers to interpret and manipulate language. In this project, we apply NLP to spontaneous speech obtained in cognitively normal elderly persons and in patients who are in the early stages of Alzheimer's disease. We investigate to what extent NLP features of speech are related to individual brain properties: regional volume, functional connectivity and ...