Projects
Improving treatment strategies for different depressive disorders by discovery of novel drug target candidates and discriminatory diagnostic biomarkers. University of Antwerp
Using molecular signaling profile in white blood cells measured by highly-sensitive mass spectrometry (MS)-based proteomics in the differential diagnosis between major depressive disorder and bipolar disorder. University of Antwerp
Inflammation-based stratification for adjunctive immune targeting in major depressive disorder KU Leuven
This doctoral project will focus on the role of the immune system in the evolution and treatment of major depression. In 2018, 6% of people over the age of 15 had a depressive disorder in the Flemish Region. In 2019, this was 36 million people per year for Europe, good for 92 billion euros in annual costs. The WHO estimates that depression will be one of the leading causes of disease burden by 2030. Depression, however, is very heterogeneous, ...
Inflammation-based stratification for immune-targeted Augmentation in major depressive disorder (INSTA-MD). University of Antwerp
INSTA-MD: INflammation-based Stratification for immune-Targeted Augmentation in Major Depressive disorder KU Leuven
The goal of this project is to offer a clear cut augmentation strategy for the first line treatment of major depressive disorder.
More specifically to tackle the treatment resistance (i.e. non-remission after two consecutive trials of first-line antidepressants) in 30-40% of cases, partially related to an immunemediated subtype of MDD. With the use of immune-based stratification, this immune-subtype can already be screened for by general ...
TBM (Applied Biomedical Research with a Primary Societal finality) project: INSTA-MD: INflammation-based Stratification for immune- Targeted Augmentation in Major Depressive disorder Vrije Universiteit Brussel
Psychological and behavioral trait-frailties in the etiopathogenesis of severe major depressive disorder. University of Antwerp
Electroconvulsive therapy (ECT) in the Major Depressive Disorder : further research into ECT impact on psychomotor and cognitive symptoms and to optimize maintenance treatment schedules. University of Antwerp
2015 Narsad Independent Investigator grant: Electrophysiological markers of reinforcement learning at baseline predict treatment outcome in major depressive disorder after accelerated theta burst stimulation of the DLPFC Ghent University
In this Project, we would like to tackle an utmost important question or challenge in psychopathology and affective neuroscience nowadays (namely to assess whether specific EEG/ERP correlates of reinforcement learning could provide valid and reliable biomarkers of Anhedonia in colinically depressed patients, who are currently enrolled in an ambulatory psychiatric treatment study based on neurostimulation at the Ghent University Hospital), and ...