Projects
Unraveling defects in the human innate immune response: Diagnosis of inherited disorders in the NF-κB pathway KU Leuven
Primary immunodeficiencies are inherited diseases that predispose children and adults to recurrent bacterial, viral, and/or fungal infections. The awareness for primary immunodeficiencies is still limited in routine clinical practice and many patients are diagnosed too late to prevent life-threatening infections by appropriate therapy. Toll-like/IL-1R (TIR) receptors and the associated NF-κB signaling pathway are important mediators of the ...
Development of a minimally-invasive test for accurate diagnosis of Cancer of Unknown Primary (CUP) using DNA methylation profiling Ghent University
Three to five percent of people who are confronted with cancer will be diagnosed with Cancer of Unknown Primary (CUP); a metastasized cancer of which the tissue-of-origin cannot be determined. If possible, a biopsy of the tumor will be taken for pathological examination, but this can take up to two weeks to plan, execute and analyze. Diagnosis usually requires multiple rounds of immunostaining, a slow and costly method that leaves about 34% ...
SOCMA (Singlet Oxygen-based photoelectrochemical bioplatform for cancer mutations): from clinical current technologies with limitations towards innovative tools for early diagnosis and monitoring (SOCMA). University of Antwerp
Morphological Uterus Sonographic Assessment (MUSA) project: Preoperative diagnosis of myometrial lesions using imaging (MUSA-1) and liquid biopsies (trans-MUSA). KU Leuven
Capability and impact of a (semi-)continuous digital cardiac rhythm monitor for the diagnosis of atrial fibrillation in a real-world, at-risk patient population. Hasselt University
The use of artificial intelligence for EEG-based diagnosis of epilepsy after a first seizure Ghent University
Fetal cell isolation and characterization for cell-based non-invasive prenatal genetic diagnosis Ghent University
Size-exclusion micro-fluidic technology will be developped to capture fetal trophoblasts from maternal peripheral blood, allowing downstream massively parallel sequencing analyses. These methods can be used to develop non-invasive prenatal testing (NIPT) providing diagnoses that can currently only be obtained by invasive techniques.