Projects
Diagnostics and recovery of neuromotor function following a traffic accident in children: study of neural structure-function relations with respect to movement coordination. KU Leuven
"Capturing the CAP4": a new class of diagnostics fro Trypanosomatidae infections. KU Leuven
Intracochlear diagnostics: Understanding and improving the bionic ear solution to deafness KU Leuven
Cochlear implant (CI) electrodes are considered the most successful sensory solution over time for severe to complete deafness. Despite its clinical success, little is known on how to optimally preserve the residual hearing function and to avoid scar tissue in order to allow future reimplantation. This project aims to study the cochlea, where the hair cells are located, using dielectric spectroscopy, an electrical analysis technique that ...
Next-generation sequencing in diagnostics: development of normative perspectives for the return of results KU Leuven
Although next generation sequencing technologies are now well-embedded into clinical care, there is still debate as to which results should be returned to patients and how much control patients should have over which results they receive. This research will provide critical guidance in the ethical and social challenges associated with the return of results from NGS performed in the diagnostic setting. To address this challenge, this study ...
Taking ovarian cancer diagnosis to the next level: differential diagnosis of malignancy type, and added value of advanced data sources such as MRI, proteomics, circulating tumour DNA and circulating tumour cells KU Leuven
Excellent tools to predict whether a detected ovarian tumour is benign or malignant prior to surgery are pivotal for several reasons: (1) currently a minority of ovarian cancers is treated by experienced gynaecological oncologists, (2) the value of screening for ovarian cancer has not been established, and (3) ovarian cancer is largely asymptomatic in its early stages such that accurate diagnosis is paramount to optimize survival. The ...
Increasing diagnostic yield in genetic childhood onset epilepsies through advanced multi-omics methods and improving mechanistic insights through the study of microglia-containing brain organoids. University of Antwerp
Optical genome mapping for comprehensive genetic analysis of sarcomas in a diagnostic setting. KU Leuven
Malignant soft tissue and bone tumors, also called sarcomas, are rare mesenchymal tumors that are characterized by a high heterogeneity in terms of histological presentation, clinical disease course and underlying genetic landscape. The identification of genetic aberrations significantly adds to a correct diagnosis of sarcomas, which is strongly associated with patient treatment and outcome. However, detecting these genetic aberrations in ...
The role of pannexin1 channels in non-alcoholic steatohepatitis: therapeutic and diagnostic relevance. Vrije Universiteit Brussel
emerged as key players in inflammation, which is associated with a
plethora of diseases. Among those is non-alcoholic steatohepatitis
(NASH), being the predominant type of chronic liver disease in
Western countries. The present project will investigate the role of
Panx1 channels in NASH at the transcriptional, translational and
functional ...
Optimizing the Pulmonary Hypertension Diagnostic Network in Belgium. KU Leuven
This doctoral project centers around the optimization of pulmonary hypertension (PH) diagnostics. Firstly a predictive tool for post-capillary PH will be validated in a prospective multicenter observational study (Optiek study). The tool was designed using artificial intelligence and implements non-invasive patient information. Secondly the difference in lung water between post- and precapillary PH will be investigated (HELP-Preserved study). ...