Publications
Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer KU Leuven
Mutation analysis of mitochondrial DNA 12SrRNA and tRNASer(UCN) genes in non-syndromic hearing loss patients Ghent University University of Antwerp
Mutation and methylation analysis of circulating tumor DNA can be used for follow-up of metastatic colorectal cancer patients University of Antwerp
Partial genomic structure, mutation analysis and mapping of the porcine inhibitor of DNA binding genes ID1, ID2, ID3 and ID4 Ghent University
Clinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant KU Leuven
Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype Vrije Universiteit Brussel
Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis and colorectal cancer, but the complete phenotype is unknown. We describe 29 individuals carrying biallelic germline NTHL1 mutations from 17 families, of which 26 developed one (n = 10) or multiple (n = 16) malignancies in 14 different tissues. An unexpected high breast cancer incidence was observed in female carriers (60%). Mutational signature analysis ...
Diagnostic Validation of a Comprehensive Targeted Panel for Broad Mutational and Biomarker Analysis in Solid Tumors Hasselt University
Mutational analysis of the carbohydrate binding activity of the tobacco lectin KU Leuven Ghent University
Whole genomes redefine the mutational landscape of pancreatic cancer Vrije Universiteit Brussel
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing and copy number variation (CNV) analysis of 100 pancreatic ductal adenocarcinomas (PDACs). Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be important in pancreatic cancer (TP53, SMAD4, CDKN2A, ARID1A and ROBO2) and new candidate drivers of pancreatic carcinogenesis ...