Publications
Relationship between time in range, glycemic variability, HbA1c and complications in adults with type 1 diabetes mellitus Vrije Universiteit Brussel KU Leuven University of Antwerp
PURPOSE: Real-time continuous glucose monitoring (RT-CGM) provides information on glycaemic variability (GV), time in range (TIR) and guidance to avoid hypoglycemia, thereby complimenting HbA1c for diabetes management. We investigated whether GV and TIR were independently associated with chronic and acute diabetes complications.
METHODS: Between September 2014 and January 2017 515 subjects with type 1 diabetes using sensor-augmented ...
N-Glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters Ghent University
Acid-base and electrolyte disturbances in patients with diabetes mellitus Vrije Universiteit Brussel
Early Endothelial Dysfunction in Type 1 Diabetes Is Accompanied by an Impairment of Vascular Smooth Muscle Function Vrije Universiteit Brussel
Background: A large yet heterogeneous body of literature exists suggesting that endothelial dysfunction appears early in type 1 diabetes, due to hyperglycemia-induced oxidative stress. The latter may also affect vascular smooth muscles (VSM) function, a layer albeit less frequently considered in that pathology. This meta-analysis aims at evaluating the extent, and the contributing risk factors, of early endothelial dysfunction, and of the ...
Screening for coeliac disease in 1624 mainly asymptomatic children with type 1 diabetes Vrije Universiteit Brussel
OBJECTIVES: To investigate the frequency of coeliac disease (CD)-specific human leucocyte antigen (HLA) genotypes in paediatric patients with type 1 diabetes (T1D), who are known to have a higher prevalence of CD than the general population, and to evaluate whether HLA genotyping is a suitable first-line screening method for CD.
STUDY DESIGN: The study was a multicentre observational analysis of patients with T1D aged <20 years of ...
Prevalence of nocturnal hypoglycemia in free-living conditions in adults with type 1 diabetes Vrije Universiteit Brussel
OBJECTIVE: Studies investigating strategies to limit the risk of nocturnal hypoglycemia associated with physical activity (PA) are scarce and have been conducted in standardized, controlled conditions in people with type 1 diabetes (T1D). This study sought to investigate the effect of daily PA level on nocturnal glucose management in free-living conditions while taking into consideration reported mitigation strategies to limit the risk of ...
Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2) Vrije Universiteit Brussel
BACKGROUND: Diabetic retinopathy remains a leading cause of visual loss in people of working age. We examined whether candesartan treatment could slow the progression and, secondly, induce regression of retinopathy in people with type 2 diabetes.
METHODS: We did a randomised, double-blind, parallel-group, placebo-controlled trial in 309 centres worldwide. We recruited normoalbuminuric, normotensive, or treated hypertensive people with ...
Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial Vrije Universiteit Brussel Ghent University KU Leuven
BACKGROUND: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the ...
Diabetes associated with pancreatic ductal adenocarcinoma is just diabetes Vrije Universiteit Brussel
BACKGROUND: Identification of a specific diabetes signature associated to pancreatic ductal carcinoma (PDAC) could be a key to detect asymptomatic, early stage tumors. We aim to characterize the clinical signature and the pathogenetic factors of the different types of diabetes associated with PDAC, based on the time between diabetes and cancer diagnosis.
METHODS: Prospective observational study on 364 PDAC patients admitted to a ...