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A facile route to heterotelechelic polymer prodrug nanoparticles for imaging, drug delivery and combination therapy Ghent University

Daniele Vinciguerra, Stephanie Denis, Julie Mougin, Merel Jacobs, Yohann Guillaneuf, Simona Mura, Patrick Couvreur, Julien Nicolas
A facile and general synthetic methodology has been developed to prepare high drug loading heterotelechelic polymer prodrug nanoparticles; that are nanoparticles obtained by formulation of linear polymers bearing two different molecules at both extremities (at least one of them being a drug). The method relied on the combination of the "drug-initiated" method to obtain a-functional polymer prodrugs by nitroxide-mediated polymerization, followed ...

A new drug combination therapy for treatment-naive patients with HIV-1 infection, consisting of raltegravir, emtricitabine and tenofovir disoproxil fumarate KU Leuven

Erik De Clercq
A new drug combination regimen, consisting of raltegravir, emtricitabine and tenofovir disoproxil fumarate (TDF), is described for the treatment of HIV-1 infection. This new drug combination regimen is applicable to the treatment of drug-naïve HIV-1-infected patients. It extends the use of the drug combinations to a new class of anti-HIV drugs, i.e. raltegravir, targeted at a new site in the HIV-1 replicative cycle, namely the HIV-1 integrase. ...

Treatment with a fixed dose combination antiretroviral therapy drug containing tenofovir, emtricitabine and efavirenz is associated with cardioprotection in high calorie diet-induced obese rats Hasselt University

Frans EVERSON, Amanda Genis, Temitope Ogundipe, Patrick DE BOEVER, Nandu Goswami, Amanda Lochner, Dee Blackhurst, Hans Strijdom
HIV-infection, certain antiretroviral drug classes, especially protease inhibitors (PI), and obesity are associated with increased ischaemic heart disease (IHD) risk. However, the effect of PI-free fixed dose combination (FDC) antiretroviral therapy (ART) on hearts exposed to ischaemia-reperfusion injury (I/R) is unknown, particularly in obesity. This is becoming relevant as World Health Organisation guidelines recommend a FDC ART containing ...

New insights into combinational drug therapy to manage congestion in heart failure Vrije Universiteit Brussel Hasselt University

Frederik Hendrik Verbrugge, Lars Grieten

Congestion is the most important contributor to morbidity and mortality in heart failure. In patients without congestion, maintaining a neutral sodium balance is imperative to prevent evolving volume overload. Adequate use of neurohumoral blockers, in combination with dietary sodium restriction, is essential and may preclude the need for maintenance diuretic therapy. If volume overload still prevails, loop diuretics remain the mainstay ...

Preclinical data on the combination of cisplatin and anti-CD70 therapy in non-small cell lung cancer as an excellent match in the era of combination therapy Ghent University University of Antwerp

Julie Jacobs, Vanessa Deschoolmeester, Christian Rolfo, Karen Zwaenepoel, Jolien Van den Bossche, Christophe Deben, Karen Silence, Hans de Haard, Christophe Hermans, Sylvie Rottey, et al.
In contrast to the negligible expression of the immunomodulating protein CD70 in normal tissue, we have demonstrated constitutive overexpression of CD70 on tumor cells in a subset of primary non-small cell lung cancer (NSCLC) biopsies. This can be exploited by CD70-targeting antibody-dependent cellular cytotoxicity (ADCC)-inducing antibodies. Early clinical trials of these antibodies have already shown promising results in CD70-positive ...

The status of combination therapy for visceral leishmaniasis: an updated review Institute of Tropical Medicine

Johan van Griensven, Thomas Pc Dorlo, Ermias Diro, Carlos Costa, Sakib Burza

For the past 15 years, trials of combination therapy options for visceral leishmaniasis have been conducted with the aim of identifying effective, and safe treatment regimens that were shorter than existing monotherapy regimens and could also prevent or delay the emergence of drug resistance. Although first-line treatment currently relies on combination therapy in east Africa, this is not true in Latin America owing to disappointing trial ...

The optimal combination therapy for the treatment of early rheumatoid arthritis Vrije Universiteit Brussel KU Leuven

Diederik De Cock, Sabrina Meyfroidt, Patrick Verschueren

INTRODUCTION: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition traditionally viewed as a severe destructive disease affecting physical health and global wellbeing. The treatment strategies for RA have changed in the last decades from mainly symptomatic towards a more vigorous and targeted approach.

AREA COVERED: Reviewing recent literature enhanced by own expertise and research, a case is made for starting ...