Projects
Sports scheduling. KU Leuven
The organ history of the premonstratensian abbey of Averbode ca. 1434-2001. Six centuries of organ building art in Brabant. KU Leuven
In the musicology of the Netherlands, the history of organ construction has its own place. For the Southern Netherlands, the organ history of the abbey of Averbode is particulary interesting. The size of the preserved old documents or the archive pieces go back to the fifteenth century. Other churches or abbeys also have valuable information, but it is often fragmented. Not only the size of the archives is important, but also the continuity. ...
Solving missing heritability in inherited retinal diseases using integrated omics and gene editing in human cellular and animal models Ghent University
Erfelijke retinale ziekte (IRD) is een belangrijke oorzaak van vroeg optredende blindheid die 350.000 mensen in Europa treft. Er is aanzienlijke vooruitgang geboekt in de genomische onderbouwing van IRD, die heeft geleid tot nieuwe therapieën die de kliniek binnenkomen. Ondanks deze vooruitgang zijn er belangrijke hiaten in de kennis die een moleculaire diagnose in meer dan de helft van de gevallen belemmeren. Wij en anderen hebben een ...
Charcot-Marie-Tooth disease, peripheral myelin protein 22, Schwann cells, dental pulp stem cells, induced pluripotent stem cells Hasselt University
MinE: International border-crossing genetic research for ALS KU Leuven
Although there are clear indications that hereditary risk factors form the basis of all forms of ALS (both familial ALS and sporadic ALS), many of these risk factors are unprecedented to date. To map these inherited risk factors, large-scale international research is required, comparing the genetic material of a large group of ALS patients with that of healthy control subjects. This is the objective of this project.
Next generation phenotyping and genotyping in inherited primary cardiac arrhythmia syndromes and cardiomyopathies KU Leuven
The relation between the genotype and phenotype of primary arrhythmia syndromes (PAS) and cardiomyopathies (CMP) is complex and ever expanding. In the first part of this thesis project, we evaluated the value of both novel and existing electrocardiographic parameters in the diagnosis and prognosis of these patients. We proposed a novel method for evaluation of the QT interval based on the patient’s own QT rate dependence profile obtained from ...
Cis-regulatorische mapping van de RPE-geexpresseerde transcriptie factor OTX2 Ghent University
Corbo et al. (2010) genereerde een cis-regulatorische map van fotoreceptor-specifieke transciptiefactor CRX in de muis. Retinal pigment epitheel (RPE)-geexpresseerde genen zijn niet vertegenwoordigd in deze dataset. cellijnen. Exoom data van index patienten met retinale dystrofieen (RD) zal gefilterd worden tegen gekende RD genen, en tegen CRX, NRL en OTX2 cis-regulatorische datasets.