Probe development for molecular imaging of low-voltage gated calcium channels (LTCC). KU Leuven
Normal cardiac function and regular heart rhythm are responsible for our well-being. Cardiac ion channels are pore-forming membrane proteins that orchestrate heart rhythm and contraction through myocardial action potentials. Cardiac low voltage-gated Ca2+ channels (LTCC) define the shape of the action potential in cardiomyocytes and promote excitation-contraction coupling. Previous electrophysiological in vitro studies have revealed that ...