Epigenetic approach to ALL combinational therapies. KU Leuven
T-ALL is a complex cancer in which multiple lesions accumulate in the genome of hematopoietic progenitors. One frequent alteration is the activation of JAK/STAT pathway, leading to increased cell proliferation and survival. These alterations also affect epigenetic regulators, altering the epigenetic landscape of leukemic cells and further contributing to cancer development. Although current therapy has increased T-ALL prognosis, it is highly ...