Projects
Galactose rewires metabolism in the treatment of congenital disorders of glycosylation. KU Leuven
Congenital disorders of glycosylation (CDG) are a group of individually rare diseases that often severely affect multiple organs. On a biochemical level there is a malfunction of the glycosylation machinery that normally puts sugar antennas on most proteins in order that they can perform their function properly. Usually, there is no treatment for these CDG. A notable exception are a group of CDG that are characterize by a deficit of galactose ...
Unraveling kidney clearance mechanisms of nanobodies Vrije Universiteit Brussel
In vivo Directed Evolution of Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase in Saccharomyces cerevisiae Using an Orthogonal DNA Replication System KU Leuven
To create an efficient and effective solar fuels process that combines solar electricity with biological organisms, any participatory enzymes in the cells need to have sufficiently high turnover rates to match the input of solar energy. A substantial breakthrough in this regard would be to develop an improved RuBisCO enzyme, which fixes CO2 from the atmosphere, with enhanced turnover rate and selectivity. In nature, RuBisCO has slow turnover ...
SBO project with a primary economic finality aimed at the transfer to existing companies: Computational Modelling of Thermo-Elastohydrodynamic Lubricated Contacts Vrije Universiteit Brussel
Computational Modelling of Thermo-Elastohydrodynamic Lubricated Contacts KU Leuven
In current CONTACTLUB project, we envisage to develop reliable, accurate and experimentally well-validated computational models for dynamic Thermo-Elasto-Hydrodynamic Lubricated (TEHL) contacts. Particular focus lies on (i) the dynamic response of TEHL contacts to variable loads and velocities (oscillating motion, vibrations,…) and (ii) the influence of TEHL contact dynamics to structural transmission of vibrations and noise generation in ...
Radiation hardened high-speed digital circuits with multi-cell upset mitigation techniques for reliable communication links in nanoscale technologies KU Leuven
In this research project, innovative circuit techniques will be developed to enable low power, extremely high-speed radiation hardened digital communication links. Such communication channels are required in complex nuclear facilities such as the Large Hadron Collider, nuclear fusion power plants and high-performance satellites. Generally, digital chips become faster each year with smaller transistors, but they also become more sensitive to ...
SCOREPLUS: Scalable Node Representation Learning in Customer Networks: New Techniques and Application. KU Leuven
This dissertation aims to bridge the gap between state-of-the-art representation learning and business applications, in particular fraud detection.
Representation learning is a structured and automated feature engineering approach, circumventing manual feature creation, which is inflexible, expensive, tedious, and error-prone. We focus on network representation learning techniques that transform a non-Euclidean network topology into a ...
CARTiPLEX: Advanced Manufacturing and 3D Bioprinting of Complex Stratified Cartilage Tissues KU Leuven
Current tissue engineering strategies based on combinations of stem cells, growth factors and biomaterials, rely on trial and error approaches, giving limited and unpredictable in vivo outcomes. Recently a biomimetic methodology for in vitro process design was described, inspired by in vivo developmental stages of tissue formation. This strategy suggests a gradual and concerted progression of cell growth and differentiation, leading to the ...