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Combining primary care surveillance and a meta-analysis to estimate the incidence of the clinical manifestations of Lyme borreliosis in Belgium, 2015–2017 Ghent University

Laurence Geebelen, Dieter Van Cauteren, Brecht Devleesschauwer, Sarah Moreels, Katrien Tersago, Herman Van Oyen, Niko Speybroeck, Tinne Lernout
Lyme borreliosis (LB) is an important tick-borne disease which can cause a broad range of symptoms mainly affecting the skin, the nervous system and the joints. This study aims to estimate the incidence of the different clinical manifestations of LB in Belgium. The incidence of erythema migrans (EM) was estimated through the network of sentinel general practices at 97.6/100,000 inhabitants (uncertainty interval [UI] 82.0–113.0) for the period ...

Incidence and management of presumption of Lyme borreliosis in Belgium : recent data from the sentinel network of general practitioners Ghent University Vrije Universiteit Brussel

Katrien Vanthomme, N. Bossuyt, N. Boffin, V. Casteren
An increasing incidence of tick bites and Lyme disease has been noticed internationally. The aims of this study are threefold: to estimate the incidence of tick bites and erythema migrans, to assess the compliance of the general practitioners (GPs) with the recommendations about the management of tick bites and erythema migrans, and finally, to have a look at the evolution over time, both on incidence and management. We used data of the Belgian ...

Surveillance perspective on Lyme borreliosis across the European Union and European Economic Area Institute of Tropical Medicine

Cees C van den Wijngaard, Agnetha Hofhuis, Mariana Simões, Ente Rood, Wilfrid van Pelt, Herve Zeller, Wim Van Bortel

Lyme borreliosis (LB) is the most prevalent tick-borne disease in Europe. Erythema migrans (EM), an early, localised skin rash, is its most common presentation. Dissemination of the bacteria can lead to more severe manifestations including skin, neurological, cardiac, musculoskeletal and ocular manifestations. Comparison of LB incidence rates in the European Union (EU)/European Economic Area (EEA) and Balkan countries are difficult in the ...

Non-specific symptoms and post-treatment Lyme disease syndrome in patients with Lyme borreliosis: a prospective cohort study in Belgium (2016-2020) KU Leuven Ghent University

Paul De Munter, Bénédicte Dubois, Rene Westhovens
BACKGROUND: Patients with Lyme borreliosis (LB) may report persisting non-specific symptoms such as fatigue, widespread musculoskeletal pain or cognitive difficulties. When present for more than 6 months and causing a reduction in daily activities, this is often referred to as post-treatment Lyme disease syndrome (PTLDS). This study aimed to compare the occurrence of symptoms between LB patients and controls, to estimate the proportion of ...

Lyme borreliosis in Belgium University of Antwerp Ghent University

Laurence Geebelen, Brecht Devleesschauwer, Tinne Lernout, Katrien Tersago, Yves Parmentier, Herman Van Oyen, Niko Speybroeck, Philippe Beutels
Background Lyme borreliosis (LB) is the most common tick-borne disease in Europe and North America, yet its economic burden remains largely unknown. This study aimed to estimate the economic cost associated with the different clinical manifestations of LB in Belgium. Methods An incidence approach and societal perspective were used to estimate the total cost-of-illness for LB in Belgium. Costs were calculated for patients with erythema migrans ...

Tekenbeten en Lyme-borreliose University of Antwerp

Peter Winderickx, Sofie Acke, Mathieu Verbrugghe, Marie-Noëlle Schmickler, Koen De Schrijver
De incidentie in België van erythema migrans in het kader van de ziekte van Lyme-borreliose (LB) bedroeg 9,8 diagnoses per 10.000 inwoners in 2015 en neemt nog toe. Boswachters, natuur- en terreinwerkers zijn hoogrisicoberoepsgroepen want zij werken in het tekenseizoen van maart tot oktober. Preventiemogelijkheden worden niet steeds toegepast. De onderzoeksvraag luidde: wat zijn de factoren die het al dan niet toepassen van preventieve ...

The HUMTICK study: protocol for a prospective cohort study on post-treatment Lyme disease syndrome and the disease and cost burden of Lyme borreliosis in Belgium KU Leuven University of Antwerp

Veroniek Saegeman
BACKGROUND: In Belgium, different routine surveillance systems are in place to follow-up Lyme borreliosis trends. However, accurate data on the disease and monetary burden for the different clinical manifestations are lacking. Despite recommended antibiotic treatment, a proportion of Lyme patients report persisting aspecific symptoms for six months or more (e.g. fatigue, widespread musculoskeletal pain, cognitive difficulties), a syndrome now ...

The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis Institute of Tropical Medicine

M.M.G. Leeflang, C W Ang, J Berkhout, H A Bijlmer, Wim Van Bortel, A H Brandenburg, N D Van Burgel, A P Van Dam, R B Dessau, V Fingerle, et al.

BACKGROUND: Interpretation of serological assays in Lyme borreliosis requires an understanding of the clinical indications and the limitations of the currently available tests. We therefore systematically reviewed the accuracy of serological tests for the diagnosis of Lyme borreliosis in Europe.

METHODS: We searched EMBASE en MEDLINE and contacted experts. Studies evaluating the diagnostic accuracy of serological assays for Lyme ...

Epidemiologie van de ziekte van Lyme vastgesteld door huisartsen in 2008 en 2009 Ghent University

Katrien Vanthomme, Nathalie Bossuyt, Nicole Boffin, Viviane Van Casteren
Op internationaal vlak is er een stijgende trend in de incidentie van tekenbeten en de ziekte van Lyme.Ook de incidentiecijfers van de Belgische peillaboratoria van infecties met Borrelia burgdorferi wijzenin die richting. Om in te schatten of het aantal nieuwe gevallen inderdaad toeneemt en of de aanpakvan de huisartsen verbeterd is, registreerde het netwerk van huisartsenpeilpraktijken in 2008 en 2009alle nieuwe gevallen van tekenbeten, ...