A "stepping-stone mechanism" for preprotein secretion through the Sec translocase KU Leuven
More than one third of all proteins synthesized in the cytoplasm are destined to be exported from it. The essential process that enables correct localization of this significant number of proteins, either by letting them pass through the membrane or by allowing their embedment into the membrane, is called secretion. In order to understand the secretion reaction in detail, the ubiquitous Sec pathway was chosen as the main focus of research in ...