Publications
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The spectrum of Lewy Body brain disorders University of Antwerp
Activation of ErbB4 attenuates atrial fibrillation in mice University of Antwerp
Atrial fibrillation (AF), the most common arrhythmia, results from electrical and structural remodeling of the atria. Current therapies focus on symptomatic treatment and do not target the structural problem. This implies a high medical need for new AF therapies. The neuregulin-1 (NRG1)/ERBB system plays a compensatory role during heart failure by acting on cardiomyocytes and mitigates fibrosis in different tissues, including the myocardium. In ...
Application of solid lipid nanoparticles as a drug delivery platform for parenteral and oral administration University of Antwerp
The development of new drug molecules is an important element of the extended lifespan and improved human health around the globe. Many new drug candidates are highly lipophilic causing solubility and formulation stability issues. This poses a challenge for formulation scientists to develop an optimal drug delivery system for oral and parenteral administration of these drugs. Solid lipid nanoparticles (SLNs) have attracted increasing attention ...
Unravelling disease signatures in Charcot-Marie-Tooth disease using induced pluripotent stem cells University of Antwerp
Charcot-Marie-Tooth (CMT) disease is an inherited peripheral neuropathy caused by mutations in various genes. It is a genetically diverse group of disorders with over 1000 mutations in more than 90 genes associated with the disease. CMT affects approximately 1 in 2500 individuals worldwide and is categorized into demyelinating (CMT1) and axonal (CMT2) forms based on the primary deficits occurring in Schwann cells or neuronal axons. Despite its ...
Characterization of occurrence, metabolism and contribution to human exposure of new plasticizers present in the indoor environment University of Antwerp
Recently, several changes have been made to the chemical composition of products used indoors. Legacy chemicals have been replaced by “alternatives” due to evidence for adverse health effects of the former. However, there is still limited information related to the human exposure to these replacement chemicals. Therefore, there is urgent need to investigate their occurrence indoors and the extent of the human exposure to them. In this regard, ...
An integrated strategy to characterize new anti-inflammatory lead compounds derived from **Filipendula ulmaria** (meadowsweet) University of Antwerp
The scope of this PhD thesis was to develop an integrated strategy, based on natural pro-drugs and their metabolites, to characterize new anti-inflammatory lead compounds derived from Filipendula ulmaria. The plant is widely used in phytotherapy against inflammatory diseases. However, its active constituents are not exactly known. It contains many constituents, such as flavonoid glycosides, which are not absorbed. However, these compounds are ...
The identification of small-molecule ERBB4 agonists University of Antwerp
ERBB4 is a member of the epidermal growth factor subfamily of receptor tyrosine kinase receptors and regulates signaling pathways involved in cardiac development, biology and disease. The endogenous ligand NRG1 is of particular importance in the heart, signaling through the ERBB4 and ERBB2 receptor. Activation of ERBB4 by NRG1 plays well-defined roles in heart failure and elicits antifibrotic effects in the heart by attenuating cell death, ...
Routine forensic analysis of psychoactive substances University of Antwerp
Toxicological analysis requires broad screening for both therapeutically prescribed and illicit compounds, including their metabolites. This research sought to develop reliable, fast and easy-to-use analytical methods, focussing on three types of psychoactive substances: antidepressants, antipsychotics and benzodiazepines and Z-drugs. They are increasingly prescribed for long-term use, frequently encountered in routine forensic samples and often ...
Prevention of atherosclerotic plaque destabilization University of Antwerp
The stability of an atherosclerotic plaque determines its fate, either toward a low-risk lesion with a thick fibrous cap, or toward a high-risk lesion with an inflammatory necrotic core and a thin fibrous cap prone to rupture. Because a large necrotic core, induced by necrosis, is a prominent feature of advanced plaques with a major impact on atherogenesis and plaque destabilization, pharmacological modulation of necrosis represents a promising ...