Publications
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Quantum dots : versatile labels in the detection of mycotoxins Ghent University
Exploration of more personalized treatments in ovarian cancer using a pharmacodynamic protein biomarker and patient-derived xenograft technology Ghent University
Design and synthesis of M. tuberculosis thymidylate kinase inhibitors towards active whole-cell antimycobacterial agents Ghent University
The regulation and dysregulation of small heat shock proteins and an associated co-chaperone in health and disease University of Antwerp
Small heat shock proteins are molecular chaperones which prevent misfolded proteins from aggregating. Many aspects regarding the molecular mechanisms of small heat shock proteins, both in health and disease, remain to be unraveled. In this thesis we found that mammalian small heat shock proteins are targeted to the mitochondrial intermembrane space. While small heat shock proteins of plants are targeted to virtually every membrane-enclosed ...
Unraveling the nuclear function of tyrosyl-tRNA synthetase associated with Charcot-Marie-Tooth disease University of Antwerp
Aminoacyl-tRNA synthetases (aaRS) catalyse the ligation of tRNAs with their cognate amino acid, the first step in protein translation, making them indispensable in every organism. Despite being ubiquitously expressed, dominant mutations in these enzymes cause a peripheral neuropathy. This incurable disease affects the longest motor and sensory neurons in the human body leading to a progressive impairment of motor abilities and sensation, ...