Molecules for use to treat or prevent cardiac diseases Ghent University
The present invention relates to the treatment or prevention of certain cardiac diseases by targeting interactions between the ryanodine type-2 receptor (RyR2) protein and the connexin 43 (Cx43) protein. Indeed, the present invention relates to molecules -more specifically peptides- which target an FDFPDDN-containing interaction domain on the connexin 43 (Cx43) protein or which target an KNRRNPRL-containing interaction domain on the ryanodine type-2 receptor (RyR) protein, and which inhibit the opening of connexin 43 (Cx43) hemichannels present in cardiomyocytes. Hence, the latter molecules ...