Publications
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Extension of a mechanistic model for drying of single pharmaceutical granules to semi-continuous fluid bed drying Ghent University
The effect of binder types on the breakage and drying behavior of granules in a semi-continuous fluid bed dryer after twin screw wet granulation Ghent University
Current study investigated the effect of different binder types on the granule drying process and the granule breakage behavior in a semi-continuous fluid bed dryer integrated in the C25 ConsiGma-system. The studied binders (i.e. hydroxypropyl pea starch, hydroxypropyl methylcellulose E15, polyvinylpyrrolidone K12, and starch octenyl succinate CO 01) required different liquid amounts to produce similar granule quality. These different liquid ...
Breakage and drying behaviour of granules in a continuous fluid bed dryer: Influence of process parameters and wet granule transfer KU Leuven Vrije Universiteit Brussel Ghent University
Although twin screw granulation has already been widely studied in recent years, only few studies addressed the subsequent continuous drying which is required after wet granulation and still suffers from a lack of detailed understanding. The latter is important for optimisation and control and, hence, a cost-effective practical implementation. Therefore, the aim of the current study is to increase understanding of the drying kinetics and the ...
Two-dimensional moisture content and size measurement of pharmaceutical granules after fluid bed drying using near-infrared chemical imaging Ghent University
In pharmaceutical wet granulation, drying is a critical step in terms of energy and material consumption, whereas granule moisture content and size are important process outcomes that determine tabletting performance. The drying process is, however, very complex due to the multitude of interacting mechanisms on different scales. Building robust physical models of this process therefore requires detailed data. Current data collection methods only ...