ZAP post in functional genomics and genomic bio-computing Ghent University
ZAP post in functional genomics and genomic bio-computing (Jo Vandesompele)
ZAP post in functional genomics and genomic bio-computing (Jo Vandesompele)
This proposal deals with personalized functional genomics in Mendelian disorders. We will tackle non-‐coding variation by NGS approaches. We will use state-‐of-‐the-‐art knockdown, knockout and
rescue experiments in model organisms. Furthermore, functional assays in patient-‐derived cellular models such as hiPSCs will lead to understanding of mutations and mechanisms.
In addition, we will optimize PGD-‐NGS. ...
The focus of my proposed research is on the ecology of emerging zoonotic viruses, both in their natural and dead-end host context. I propose to investigate these viruses’ clinical relevance for and the genetic susceptibility of their host, and to explore and predict the mechanisms that determine the capability of these reservoir-borne viruses to switch hosts as well as their pathogenic potential. To achieve these goals, I am finalizing an ...
BOF-ZAP-ambt in Bioinformatics, functional genomics, RNA-biology, oncology (Pieter Mestdagh)