GM-CSF as crucial rheostat of the allergic airways Ghent University
Asthma is a heterogeneous respiratory disease in which many immune and structural lung cells act in concert to amplify local inflammatory processes and cause airway remodeling resulting in clinical symptoms and chronic disease. Upon allergen-induced activation of airway epithelial (EP) cells, there is early production of IL-1α that subsequently acts on the IL-1R in an autocrine manner to boost further production of cytokines like GM-CSF, ...