Projects
Identification of a novel gene causing frontotemporal lobar degeneration and amyotrophic lateral sclerosis through whole genome sequencing. University of Antwerp
NXT-EYE: integrated genomics and transcriptomics for gene identification in inherited retinal degeneration Ghent University
Inherited retinal degeneration (RD) is responsible for 5% of blindness worldwide. Genetic
studies have revealed underlying molecular defects in ~50% of individuals with RD, most of
which are located in the coding portion of the genome. The advent of next-generation sequencing (NGS) has revolutionized the genetic landscape. However, the massive amount of
data produced by NGS hampers disease gene identification, requiring ...
Identification of the major determinants that explain intolerance to gene duplication in the flowering plants Ghent University
Genomes are dynamic entities that change over time. An important mechanism by which genomes
evolve novel functions is gene and genome duplication. However, not all cellular processes are
equally malleable by evolution through gene duplication. Studies in human genomes have revealed
that certain genes might be intolerant to duplication, leading to human disease. Similarly, we
recently discovered that many flowering ...
Identification of the gene regulatory networks controlling vascular development in plants – a comparative approach at single-cell resolution Ghent University
When plants colonized the land evolved specialized structures which enabled anchorage and movement of nutrients and water throughout the whole plant, the root and the vascular system. Large evolutionary changes such as this are the result of modifications of the gene regulatory network (GRN), composed of regulators controlling the expression of target genes, that controls organ development. In order to unravel the key changes which led to the ...
Identification of the key gene of 18q deletions: human embryonic stem cells as a research model in oncogenetics Vrije Universiteit Brussel
Use of an integrative classification system and next-generation sequencing strategies for gene identification in common variable immunodeficiency disorder (CVID) Ghent University
Common variable immunodeficiency disorder (CVID) is a group of diseases in which the capacity to produce antibodies (immunoglobulins, Igs) against microbial infections is impaired. There is a marked decrease in one or more Ig classes and the number and/or function of certain B lymphocyte subsets may be reduced. In addition to an increased susceptibility to infections, CVID is also associated with auto-immune and malignant conditions. The ...
Gene identification and zebrafish disease modeling of inherited bone disorders University of Antwerp
Use of an integrative classification system and next-generation sequencing strategies for gene identification in common variable immunodeficiency disorder (CVID). Ghent University
Common variable immunodeficiency disorder (CVID) is a group of diseases charachterized by a decrease in immunoglobulines and in number and/or function of B-lymphocyte subsets. Its heterogeneity complicates the elucidation of underlying disease mechanisms and gene defects.
This study aims to develop a classification of CVID patients integrating clinical data, immunophenotyping, molecular analyses and next-generation sequencing, in ...
Gene cluster identification and microbial biosynthesis of iminosugars (IMINOGENE) Ghent University
The “IMINOGENE” project focuses on the sustainable and microbial production of specialty carbohydrates useful in human and animal welfare as well as in the agro-industry. These specialty carbohydrates are currently often discovered in plants and are little investigated with regard to their microbial natural sources. Therefore, in the IMINOGENE project, the microbial biosynthesis blueprints are unraveled with advanced bioinformatics tools and ...