Identification of molecular regulators of osteoprogenitor recruitment and osteo-angiogenic coupling during bone formation using developmental models and gene expression profiling. KU Leuven
Fetal bone development as well as homeostatic bone renewal and regenerative fracture healing require osteoprogenitors to be recruited to sites of bone formation and involve a tight spatiotemporal coupling between osteogenesis and angiogenesis. The synchrony observed between these processes in previous research suggests an intense crosstalk between osteoprogenitors and endothelial cells. In fact, skeletal progenitors are increasingly ...