Projects
Identification of genes for otosclerosis and elucidation of their role in the disease process. University of Antwerp
Identification and characterisation of genes responsible for age-related hearing impairment. University of Antwerp
Identification of causal mutations in patients with unexplained mental retardation and congenital abnormalities by high throughput sequencing of selected candidate genes Ghent University
Chromosomal aberrations as well as pointmutations are an important cause of mental retardation and multipele congenital abnormalities (MR/MCA). In this project, the newest technologies in human genetics (selective resequencing) will be used to resequence 3000 candidate genes for MR/MCA in order to understand the underlying cause of MR/MCA and to gain insights in normal human embryogenesis.
Identification and characterization of new organ-specific target genes of the canonical Wnt pathway. Ghent University
Identification of virulence genes of Batrachochytrium dendrobatidis involved in amphibian keratinocyte invasion Ghent University
The pathogenesis of chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis, is poorly understood. We aim at unraveling the mechanisms used by the fungus to induce epidermal changes in amphibians.
Localization, identification and functional characterization of disease genes for retinal dystrophies. Ghent University
Identification of (new) susceptibility genes for Crohn's disease and their functional meaning. KU Leuven
Demonstration of yet undiscovered dentrification genes in Gram positive bacteria via whole genome sequencing Ghent University
Denitrification is a redundant enzymatic process. Known denitrification genes could not yet been demonstrated in many gram positive bacteria despite the presence of a clear denitrification capacity. In this project, we will try to underpin the hypothesis that unknown genes are involved in the evolution of fixed nitrogen into nitrogen gas by whole genome sequencing of a selection of denitrifying bacilli.