Study of the essential function of beta-actin in embryonic development and the necessity of correct localisation of beta-actin mRNA in neuronal development Ghent University
The actin cytoskeleton is the driving force for various cell motility processes. Little is known about the function of the six actin isoforms during mammalian development. During this PhD, we will investigate how loss of beta-actine influences angiogenesis and neurogenesis during embryogenesis and how mislocalisation of beta-actine mRNA leads to aberrant neuronal differentiation and angiogenesis.
Molecular and biochemical characterization of the globin gene family in Caenorhabditis elegans Ghent University
In silico analysis revealed the presence of 33 globin genes in the genome of C. elegans. The purpose of the project is to unravel their functions. Therefore the following approaches will be performed: Localisation of expression using GFP-reporter constructs. Expression profiling under hypoxia. Phenotype analysis under gene silencing. Identification cloning of a subset of globins and subsequent biochemical study of their ligand binding ...
Molecular genetics of early-onset Alzheimer's disease. University of Antwerp
Targeting the lineage-specific long non-coding RNA LINC01212 as an effective anti-melanoma strategy. KU Leuven
Melanomas are aggressive malignant neoplasms of melanocytic origin, highly resistant to both chemotherapy and radiotherapy. As such, melanoma was viewed as an incurable beast for many decades and patients had virtually zero therapeutic options available. Fortunately, in the last few years major breakthroughs led to the introduction of effective therapies which significantly increased patients’ survival. Nonetheless, despite ...
Identification and validation of physiological substrates and interaction partners of PINK1 and LRRK2, 2 kinases linked to familial forms of Parkinson's disease. KU Leuven
Study of the role of iodothyronine deiodinases in early brain development using gain and loss of function studies in the chick embryo. KU Leuven
All organisms can adjust their form and physiology to suit changes in their environment. Economically devastating locust swarms result from an extreme type of such “phenotypic plasticity”. Depending on population density, the locust genome can manifest as one of two very different phenotypic outcomes: a lone-living “solitarious phase” or a swarming “gregarious phase”. Gregarious behaviour can arise within hours of crowding, and is soon ...
Vesicular recycling from the plasma membrane and disturbance of Ca2+ homeostase as determinants for alpha-synuclein induced cytotoxicity. KU Leuven
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the Western world. Early studies mainly focused on the involvement of environmental factors in the development of PD. More recently, evidence is increasing that genetic factors also play a major role. The first gene identified to be associated with PD encodes for α-synuclein, an unfolded protein of 140 amino acids that is ubiquitously present in the brain. In ...
This project studies the signal transduction mechanisms of the oxidative stress response in plants. For hydrogen peroxide inducible proteins, we will determine their subcellular (re)localisation during stress. For proteins with a nuclear relocalisation we will perform a U+2018cytosolic retentionU+2019 screen together with a Tandem Affinity Purification. For a selection of genes, their potential impact on stress tolerance will be assessed.