Projects
UNRAVELING THE ROLE OF CHROMATIN REGULATORS DURING EARLY HUMAN EMBRYONIC DEVELOPMENT KU Leuven
Chromatin regulation is essential for lineage specification during embryonic development. However, despite advances in our understanding of chromatin processes in mammalian development, little is known about chromatin regulation in early human embryos. Here, I will use functional perturbations in human stem cell-based embryo models, and single-cell technologies, to understand the role of chromatin regulators in early human embryonic lineage ...
Complex dynamics and regulation of the plant energy sensor SnRK1 KU Leuven
The plant SnRK1 (SNF-related kinase1) kinases are highly conserved cellular fuel gauges. In energy-depleting stress conditions, they stimulate catabolic reactions while repressing energy-consuming anabolic processes, shifting the balance from growth to survival. Consistent with their unique lifestyle, plants also have evolved specific regulatory mechanisms. Rather than being activated upon energy deficit, SnRK1 is repressed under conditions ...
Complex dynamics and regulation of the plant energy sensor SnRK1 Ghent University
The plant SnRK1 (SNF-related kinase1) kinases are highly conserved cellular fuel gauges In energy-depleting stress conditions, they stimulate catabolic reactions while repressing energy-consuming anabolic processes, shifting the balance from growth to survival Consistent with their unique lifestyle, plants also have evolved specific regulatory mechanisms Rather than being activated upon energy deficit, SnRK1 is repressed under conditions of ...
Complex dynamics and regulation of the plant energy sensor SnRK1 KU Leuven
The plant SnRK1 (SNF-related kinase1) kinases are highly conserved cellular fuel gauges. In energy-depleting stress conditions, they stimulate catabolic reactions while repressing energy-consuming anabolic processes, shifting the balance from growth to survival. Consistent with their unique lifestyle, plants also have evolved specific regulatory mechanisms. Rather than being activated upon energy deficit, SnRK1 is repressed under conditions ...
Vesicular recycling from the plasma membrane and disturbance of Ca2+ homeostase as determinants for alpha-synuclein induced cytotoxicity. KU Leuven
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the Western world. Early studies mainly focused on the involvement of environmental factors in the development of PD. More recently, evidence is increasing that genetic factors also play a major role. The first gene identified to be associated with PD encodes for α-synuclein, an unfolded protein of 140 amino acids that is ubiquitously present in the brain. In ...
HeMiBio (related to project EU376-B) Vrije Universiteit Brussel
In the project we made the following advances beyond the state of the art:
1. CELLS: We characterized for the first ...
Microtubules in the pathogenesis of neurodegenerative diseases. KU Leuven
In a second phase we will study the function of Elp3 with regards to ...
Signal transduction mechanisms of the oxidative stress response in plants Ghent University
This project studies the signal transduction mechanisms of the oxidative stress response in plants. For hydrogen peroxide inducible proteins, we will determine their subcellular (re)localisation during stress. For proteins with a nuclear relocalisation we will perform a U+2018cytosolic retentionU+2019 screen together with a Tandem Affinity Purification. For a selection of genes, their potential impact on stress tolerance will be assessed.