Transcriptome profile of the human placenta: in search of maternal and fetal genetic factors associated with preterm birth. Ghent University
Preterm birth is defined as childbirth before 37 completed weeks of pregnancy. It is the
leading cause of perinatal morbidity and mortality, leading to high costs in care and long-term disability. It accounts for 5-12 % of all live births worldwide. Multiple factors, both endogenous and exogenous to the mother seem to play a role. Genetic factors appear to be involved, as apparent from disparities between racial groups and on familial ...
Generation of interchangeable disease models for Charcot-Marie-Tooth involving tRNA-synthetases: a search for common druggable pathways. University of Antwerp
In search of genetic modifiers for aortopathy in Loeys-Dietz families with a SMAD3 mutation. University of Antwerp
Exploring the crystal structure of the EarthU+2019s inner core by Density Functional Theory and a genetic search algorithm Ghent University
All computational studies of Fe at inner core conditions where limited so far by the need to supply a priori the
most likely crystal structure(s). Genetic search algorithms have recently established themselves as a new tool in
computational materials science, and allow searching for the most stable crystal structure without any a priori
knowledge. We propose to apply this new tool to pure Fe and to Fe alloyed with one or more ...
Functional genomic research of the CLU gene as risk factor for Alzheimer's disease. University of Antwerp
Pituitary deficiency and regeneration: in search of underlying mechanisms and therapeutic targets with focus on Wnt/Lgr5 KU Leuven
The pituitary is the master endocrine gland governing normal body physiology. By regulating other endocrine glands, the pituitary steers various processes such as growth, stress, metabolism and sexual maturation. Patients with hypopituitarism suffer from a multitude of life-burdening symptoms due to insufficient production of one or several pituitary hormones. Managing this disorder currently comprises lifelong hormone replacement therapy, a ...
Tumour suppressor protein p53 contributes to various pathways involved in cell proliferation, cell death and normal cell homeostasis. It is not obvious which of these pathways is essential to block tumourigenesis; novel p53 targets and pathways may still contribute as key mechanisms to cancer inhibition.
We have identified previously unknown p53 targets in the class of long noncoding RNA through RNA expression profiling by qPCR as well ...
Pituitary deficiency and regeneration: in search of underlying mechanisms and therapeutic targets. KU Leuven
The pituitary is the ‘master gland’ producing hormones that control vital physiological processes like growth, metabolism, reproduction and stress response. Obviously, defects in pituitary function (hypopituitarism) cause severe and life-threatening health problems. Hypopituitarism is treated with lifelong hormone replacement. However, patients taking these hormones suffer from serious side effects. Moreover, administration of hormones cannot ...