Projects
Identification of the key gene of 18q deletions: human embryonic stem cells as a research model in oncogenetics Vrije Universiteit Brussel
Functional genomic research of the CLU gene as risk factor for Alzheimer's disease. University of Antwerp
Research into the genes involved in arterial tortuosity, and aortic aneurysms Ghent University
A search for new pathways in the reversal and prevention of obesity and type 2 diabetes KU Leuven
Obesity is a chronic disease that mainly develops in sedentary individuals, over-consuming a Western diet, rich in salt, sugar and fat. Obesity is a major cause of several life threatening health risks, such as type 2 diabetes (T2D). The currently available drugs have rather disappointing long-term effects. Gastric bypass procedures (GBP) have turned out to be a very effective treatment for obesity and associated T2D with a maintained effect ...
A systemic search for novel congenital disorders of Glycosylation type 1 (CDG-I), with a comprehensive evaluation of the clinical phenotypes. KU Leuven
Glycosylation is one of the most abundant protein modifications found in nature. It results from a meticulously orchestrated process involving numerous proteins for the assembly and modification of oligosaccharide chains, and their attachment onto proteins and lipids. The importance of glycosylation is illustrated by a group of diseases called Congenital Disorders of Glycosylation (CDG). To date, almost 100 distinct disorders have been ...
The search for biomarkers in systemic treatment of advanced hepatocellular carcinoma. KU Leuven
The combination of immune checkpoint inhibitors with anti-angiogenic agents has revolutionized the treatment landscape of advanced hepatocellular carcinoma (HCC). As more therapies become available, each effective in a, yet undefined, subgroup of patients, managing advanced HCC well has become increasingly complex. With the fast pace at which the landscape evolves and the lack of data on head to head comparisons of novel regimens, an ...
Transcriptome profile of the human placenta: in search of maternal and fetal genetic factors associated with preterm birth. Ghent University
Preterm birth is defined as childbirth before 37 completed weeks of pregnancy. It is the
leading cause of perinatal morbidity and mortality, leading to high costs in care and long-term disability. It accounts for 5-12 % of all live births worldwide. Multiple factors, both endogenous and exogenous to the mother seem to play a role. Genetic factors appear to be involved, as apparent from disparities between racial groups and on familial ...
The search for the origin of chromosomal abnormalities in human preimplantation embryos Vrije Universiteit Brussel
cleavages of the embryo. We want to study the ...