Subsidiation centers for medical genetics 2010 Ghent University
Complex genetics of Alzheimer's disease and related disorders. University of Antwerp
Neurodegenerative disorders are extremely debilitating conditions. They affect motoric (ALS, Parkinson) or cognitive systems (Alzheimer, Frontotemporal dementia, Parkinson in late stages). Curative therapy is much needed but only symptomatic treatment based on neurotransmitter substitution is available for Parkinson, and more limited, for Alzheimer. All in all, for the advanced stages of neurodegenerative diseases, only palliative help can be ...
The hidden genetics of Developmental and Epileptic Encephalopathies: a multi-omics approach. University of Antwerp
Novel forward genetics screening methodology in human HEK293 cells. Ghent University
Forward genetic approaches are at the basis of much of our understanding of cellular biology. But such approaches are poorly established for mammalian cells. The aim of the project is to optimize and explore the scope of a method for 'directed cell line evolution' that makes use of the property of HEK293-cells to evolve through a more natural mutation-accumulation process.