Projects
Evolutionary and population genetic consequences of social structure and genetic relatedness on disease and adaptive landscapes of human genome KU Leuven
Research under this program will focus on the effect of social structure and kinship on processes that cause genetic differentiation within and among human populations, including those that affect the entire genomes and those resulting in differences among individual loci, those under the influence of selection and those that cause disease. I am interested to know how deviations from panmixia, including sexspecific demographic processes, in ...
Preimplantation genetic testing in equine test-tube embryos: the advent of a new era in breeding champion horses Ghent University
The high individual value of the horse results in an exponential increase in the number of in vitro produced (IVP) equine embryos. Yet, preimplantation genetic testing (PGT), involving the prelevation of cells from the embryo for genetic profiling prior to embryo transfer, is still limited to sex determination and the detection of a few monogenic traits, using multiplex PCR with variable results. The goal of this project is to develop a ...
Homologous Recombination Deficiency (HRD) as predictive and prognostic genetic marker in ovarian cancer - Bridging the gap between ‘one-size-fits-all’ and a more personalised treatment approach KU Leuven
HERCULES: DEVELOPMENT OF NEXT-GENERATION GENE THERAPY TO TREAT GENETIC MUSCLE DISORDERS Vrije Universiteit Brussel
Communicating genetic risk in the family: potential solutions to ethical challenges KU Leuven
Improved characterization of Alzheimer's disease genetic risk through fine-mapping and long-read sequencing of DNA and single-nuclei RNA. University of Antwerp
Expanding the TDP-43 proteinopathy spectrum from the neuron to the muscle: a clinical, genetic, pathological and multi-omics study paving the way for new therapeutic strategies Ghent University
A precision medicin approach for canine degenerative myelopathy combining genetic and epigenetic alterations Ghent University
This research project aims to introduce precision medicine and epigenetics research in the canine neurogenetics field. Practically, canine degenerative myelopathy will be studied with MDB-seq to identify differentially methylated regions associated with disease progression. This will be followed by the writing of a general statistical analysis framework in R that accurately predicts clinical age of onset for this disorder.
Developing novel highly precise RNA targeting CRISPR tools to study higher order functional organization of genetic networks KU Leuven
To understand how the genotype shapes the phenotype of an organism is an important problem in genetics. Moreover, higher-order genetic interactions are notoriously difficult to research. To study these interactions, specific and high-throughput tools are needed. However, current technologies, like RNA and CRISPR interference, are either unsuitable for genome-scale screens or have too variable and unpredictable efficiencies. In this PhD ...