Projects
VIB Grant for van Loo Lab_Period:2017-01-01-2021-12-31 Flanders Institute for Biotechnology
Afwerkersbeurs Emmanuel Van der Schueren Karolina: Characterization of an aggressive and microbiota-dependent colon cancer model Ghent University
Colorectal cancer (CRC) is a frequently lethal disease with very heterogeneous outcomes and drug responses. We recently developed a new, fast and fully penetrant in vivo mouse model of spontaneous CRC based on the lEC-specific mono-allelic expression of the EMT transcription factor ZEB2. ZEB2, an E-box binding transcription factor, is a crucial driver of epithelial-to-mesenchymal transition (EMT). ZEB2 was initially described as a factor ...
Role of autophagy in normal and atherosclerotic arteries University of Antwerp
Pharmacological modulation of autophagy in vascular disease. University of Antwerp
Molecular mechanisms of cellular crosstalk in skin regeneration and cancer Ghent University
Although an association between tissue damage, chronic inflammation and cancer is well established, little is known about the underlying molecular mechanisms. Here, I aim to investigate the role of candidate molecules in mediating signalling events between keratinocytes and immune cells in the wound and tumour skin microenvironment.
The H boson gateway to physics beyond the Standard Model Ghent University
In 2012, a scalar particle has been discovered at the LHC (CERN). As of today, its properties
match those of the Higgs boson of the Standard Model (SM), the current theory of
fundamental interactions. This discovery has crowned 50 years of research, including seminal
work done in Belgium by Brout and Englert. It has also opened a new era for particle
physicists, with more-than-ever pressing mysteries to face, including ...
Understanding responses and resilience of central Congo basin forests to a changing environment - FORMONCO II in DR Congo Ghent University
Strategic Research Programme: Molecular Imaging and targeting of macrophages in Inflammation (ITARMI) Vrije Universiteit Brussel
Host-microbe interaction in intestinal homeostasis: unravelling the mechanisms involved in the onset of multiple inflammation-related diseases Ghent University
While the gut microbiota comprises trillions of microbes, blood and host tissues are nearly devoid of bacteria or bacterial macromolecules. This relative sterility relies on an effective gut barrier that acts as the gatekeeper of our health. Indeed, defects in this first line of defense allow the tissue penetration of bacteria and thereby contribute to the onset of local and systemic inflammation. Strikingly, inflammation is a common ...