Projects
Mechanical behaviour of tissue spheroids from single cell properties KU Leuven
Complex biological tissues and cell colonies: active material properties of multicellular structures KU Leuven
Complex biological tissues and cell colonies behave as active materials in which the constituents, individual cells, self-organize to create complex and dynamic biological systems. In order to engineer multicellular structures, for example in tissue engineering or in the treatment of bacterial biofilms, we can harness the active mechanical properties of these materials to help steer cell and tissue fate. However, active materials exhibit ...
Development of an innovative multiscale computational model to quantitatively unravel the role of cell-matrix mechanics in angiogenesis KU Leuven
The ability of cells to migrate through a tissue in the human body is vital for many processes such as tissue development, growth and regeneration. At the same time, abnormal cell migration is observed in many diseases such as cancer. In order to discover the origin of these abnormalities and develop new treatment strategies, an improved understanding of the cell migration process and its regulation is required. Mechanics of the cell and the ...
The role of mechanics in cell culture for micro-tissue fabrication. A model-based study using self-propelled particles KU Leuven
In tissue engineering, stem cells are used to produce artificial constructs that can improve or replace biological tissue. The production of these constructs often involves a cell culture step, in which cells are multiplied and assembled in ‘micro-tissues’ with desired tissue properties. To ensure product quality, the physical micro-environment of single cells must be well-controlled during this step. Yet, the formation of this ...
Soil Modeling, Dynamic Refinement, and Shared Memory Parallelization within SPH KU Leuven
In this thesis we extendthe applicability of ...