Prediction of the Response to Peg-Interferon-Alfa in Patients With HBeAg Positive Chronic Hepatitis B Using Decline of HBV DNA During Treatment KU Leuven
Peginterferon (PEG-IFN) results in HBeAg loss combined with virologic response in only a minority of patients with HBeAg positive chronic hepatitis B. Baseline predictors of response to PEG-IFN include HBV-genotype, pre-treatment HBV DNA levels, and ALT. The aims of this study were to develop a model, which improves the baseline prediction of response to PEG-IFN for individual patients by including early HBV DNA measurements during treatment and ...