Methodological aspects of in vivo imaging of mutant huntingtin in a mouse model of Huntington's disease. University of Antwerp
Huntington's disease (HD) is an autosomal dominant disorder characterized by a progressive neurodegeneration of the striatum in the early stage and several other brain regions in a later stage. The mutation responsible for this disease is an abnormal expansion of trinucleotide CAG repeats leading to the production of a huntingtin protein with an expanded polyglutamine stretch (mHTT). Longitudinal monitoring of mHTT in a HD mouse model is thus of ...