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Dosing vitamin C in critically ill patients with special attention to renal replacement therapy Vrije Universiteit Brussel

Patrick Honoré, Herbert Spapen, Paul E Marik, Willem Boer, Heleen M Oudemans-van Straaten

RATIONALE/METHODS: The primary aim of the present contribution is to find a literature-based agreement on dose adjustments of vitamin C in critically ill patients undergoing renal replacement therapy (RRT).

AVAILABLE DATA/STUDY RESULTS: Critical illness is frequently accompanied by severe vitamin C deficiency. High-dose supplementation beneficially affects clinical outcome in small cohorts of patients with sepsis, burn injury, and ...

High-Dose Vitamin D Does Not Prevent Postoperative Recurrence of Crohn's Disease in a Randomized Placebo-Controlled Trial KU Leuven

Peter Bossuyt, Marc Ferrante
BACKGROUND & AIMS: Vitamin D deficiency is common in Crohn's disease (CD). High-dose vitamin D had anti-inflammatory effects in preclinical studies and trials of patients with CD. We performed a randomized trial to determine whether high-dose vitamin D prevents postoperative recurrence of CD after ileocolonic resection. METHODS: Patients with CD after ileocolonic resection with ileocolonic anastomosis were assigned randomly to groups given ...

Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments Vrije Universiteit Brussel University of Antwerp KU Leuven

Stefanie Vandervelden, Lina Wauters, Jan Breuls, Steffen Fieuws, Philippe Vanhove, Ives Hubloue, Magali Bartiaux, Jacques Creteur, François Stifkens, Koen Monsieurs, et al.

BACKGROUND: Sepsis is a potentially life-threatening condition characterized by a deregulated body's response to infection causing injury to its own tissues and organs. Sepsis is the primary cause of death from infection. If not recognized and treated timely, it can evolve within minutes/hours to septic shock. Sepsis is associated with an acute deficiency of Vitamin C. Despite the proof-of-concept of the benefit of administering Vitamin C in ...

Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19? KU Leuven

Adam Feyaerts, Walter Luyten
Severe acute respiratory syndrome coronavirus 2 causes the potentially fatal coronavirus disease 2019 (COVID-19). Already during the outbreak of the severe acute respiratory syndrome coronavirus 1, the use of vitamin C was suggested. Many patients with severe COVID-19 have elevated levels of the mediators interleukin-6 and endothelin-1. These mediators may explain the age dependence of COVID-19 pneumonia, the preponderance of male and obese or ...

In vitro and ex vivo evaluation of currently used and novel therapeutic strategies in HTLV-1 infection KU Leuven

Isolated in 1979, the human T-lymphotropic virus type 1 (HTLV-1) was the first human pathogenic retrovirus to be discovered. In the meantime, HTLV-1 is found worldwide, with an estimated 10 to 30 million infected individuals, and endemic regions include Sub Saharan Africa, South America, the Caribbean Islands, Japan, and Melanesia/Australia. The majority of HTLV-1-infected individuals remain clinically asymptomatic throughout their lifetimes, ...