Publications
Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology. Vrije Universiteit Brussel
histone deacetylases (HDACs) catalyse the reverse reaction. In ...
Inhibiting Histone and DNA Methylation Improves Cancer Vaccination in an Experimental Model of Melanoma Vrije Universiteit Brussel
Immunotherapy has improved the treatment of malignant skin cancer of the melanoma type, yet overall clinical response rates remain low. Combination therapies could be key to meet this cogent medical need. Because epigenetic hallmarks represent promising combination therapy targets, we studied the immunogenic potential of a dual inhibitor of histone methyltransferase G9a and DNA methyltransferases (DNMTs) in the preclinical B16-OVA melanoma ...
Histone H3 clipping in human embryonic stem cells: in pursuit of an epigenetic outcast Ghent University
Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells Vrije Universiteit Brussel
Adult neural stem cell proliferation is dynamic and has the potential for massive self-renewal yet undergoes limited cell division in vivo. Here, we report an epigenetic mechanism regulating proliferation and self-renewal. The recruitment of the PI3K-related kinase signaling pathway and histone H2AX phosphorylation following GABA(A) receptor activation limits subventricular zone proliferation. As a result, NSC self-renewal and niche size is ...