Publications
Chosen filters:
Chosen filters:
Histone H2B monoubiquitination is required to reach maximal transcript levels of circadian clock genes in Arabidopsis Ghent University
A large scale mass spectrometry-based histone screening for assessing epigenetic developmental toxicity Ghent University
Toxicoepigenetics is an emerging field that studies the toxicological impact of compounds on protein expression through heritable, non-genetic mechanisms, such as histone post-translational modifications (hPTMs). Due to substantial progress in the large-scale study of hPTMs, integration into the field of toxicology is promising and offers the opportunity to gain novel insights into toxicological phenomena. Moreover, there is a growing demand for ...
Neutrophil elastase is the 'histone H2A-specific protease' Ghent University
Fundamental changes in the epigenetic status of histones from hematopoietic stem cells might be one of the driving forces behind many malignant transformations and subsequent leukemia development. The amino-terminal tail of histones and the carboxy-tail of histone H2A protrude from the nucleosome and can be modified by many different posttranslational modifications (PTM) on at least 60 different residues, thereby mediating chromatin dynamics. ...
Histone deacetylases regulate MORE AXILLARY BRANCHED 2-dependent germination of Arabidopsis thaliana Ghent University Flanders Institute for Biotechnology
Under specific conditions, the germination of Arabidopsis thaliana is dependent on the activation of the KARRIKIN INSENSITIVE 2 (KAI2) signalling pathway by the KAI2-dependent perception of karrikin (KAR) or the artificial strigolactone analogue rac-GR24. To regulate induction of germination, the KAI2 signalling pathway relies on MORE AXILLARY BRANCHED 2 (MAX2)-dependent ubiquitination and proteasomal degradation of the repressor protein ...
Comprehensive histone epigenetics : a mass spectrometry based screening assay to measure epigenetic toxicity Ghent University
Evidence of the involvement of epigenetics in pathologies such as cancer, diabetes, and neurodegeneration has increased global interest in epigenetic modifications. For nearly thirty years, it has been known that cancer cells exhibit abnormal DNA methylation patterns. In contrast, the large-scale analysis of histone post-translational modifications (hPTMs) has lagged behind because classically, histone modification analysis has relied on site ...
Imipramine exploits histone deacetylase 11 to increase the IL-12/IL-10 ratio in macrophages infected with antimony-resistant Leishmania donovani and clears organ parasites in experimental infection Institute of Tropical Medicine
The efflux of antimony through multidrug resistance protein (MDR)-1 is the key factor in the failure of metalloid treatment in kala-azar patients infected with antimony-resistant Leishmania donovani (Sb(R)LD). Previously we showed that MDR-1 upregulation in Sb(R)LD infection is IL-10-dependent. Imipramine, a drug in use for the treatment of depression and nocturnal enuresis in children, inhibits IL-10 production from Sb(R)LD-infected ...
Synergetic effect of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes Vrije Universiteit Brussel
Both, DNA methylation and histone deacetylation play a crucial role in cancer development by silencing the expression of specific tumour suppressor genes. Several studies describe the use of combinations of DNA methyltransferase inhibitors (DNMT-i) and histone deacetylase inhibitors (HDAC-i) as an improved strategy to treat neoplasms. However, no information is available concerning their biological impact on healthy, non-malignant cells, ...
Histone deacetylase inhibitors in multiple myeloma Vrije Universiteit Brussel
Novel drugs such as bortezomib and high dose chemotherapy combined with stem cell transplantation improved the outcome of multiple myeloma patients in the past decade. However, multiple myeloma often remains incurable due to the development of drug resistance governed by the bone marrow micro-environment. Therefore targeting new pathways to overcome this resistance is needed. Histone deacetylase (HDAC) inhibitors represent a new class of ...
Toxicological and Metabolic Considerations for histone deacetylase inhibitors Vrije Universiteit Brussel
Introduction: Vorinostat and romidepsin were the first histone deacetylase (HDAC)
inhibitors (HDi) that fulfilled the preclinical promise of anticancer potential in clinical
trials. Nevertheless, they merely opened a new chapter in the history of cancer
therapy. Demonstration of their antitumour activity was a straightforward task in in
vitro setting. Proving their efficacy in vivo was much more difficult, since the ...
inhibitors (HDi) that fulfilled the preclinical promise of anticancer potential in clinical
trials. Nevertheless, they merely opened a new chapter in the history of cancer
therapy. Demonstration of their antitumour activity was a straightforward task in in
vitro setting. Proving their efficacy in vivo was much more difficult, since the ...