Publications
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Epigenetic switches of tobacco transgenes associate with transient redistribution of histone marks in callus culture Ghent University
Impact of the histone deacetylase inhibitor 4-phenylbutyrate on the clearance of apoptotic pancreatic carcinoma cells by human macrophages Ghent University
From dysregulated protein expression to histone clipping: the virtue of mass spectrometry: a proteomics tale of serendipity Ghent University
Asymmetric leaves2 and elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana Ghent University
Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors Ghent University
Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis KU Leuven
OBJECTIVES: In osteoarthritis, methylation of lysine 79 on histone H3 (H3K79me), a protective epigenetic mechanism, is reduced. Histone methylation levels are dynamically regulated by histone methyltransferases and demethylases. Here, we aimed to identify which histone demethylases regulate H3K79me in cartilage and investigate whether their targeting protects against osteoarthritis. METHODS: We determined histone demethylase expression in human ...
Effects of environmental stressors on histone modifications and their relevance to carcinogenesis: A systematic review KU Leuven
Carcinogenesis is a complex process involving both genetic and epigenetic mechanisms. The cellular molecular epigenetic machinery, including histone modifications, is associated with changes in gene expression induced by exposure to environmental agents. In this paper, we systematically reviewed publications regarding the effects of xenobiotic stressors, mainly heavy metal exposure, on specific histone modifications. We included a total of 18 ...
Interaction of the tobacco lectin with histone proteins KU Leuven Ghent University University of Antwerp
The Nicotiana tabacum agglutinin or Nictaba is a member of a novel class of plant lectins residing in the nucleus and the cytoplasm of tobacco cells. Since tobacco lectin expression is only observed after the plant has been subjected to stress situations such as jasmonate treatment or insect attack, Nictaba is believed to act as a signaling protein involved in the stress physiology of the plant. In this paper a nuclear proteomics approach was ...
Association of Prenatal Exposure to Ambient Air Pollution With Circulating Histone Levels in Maternal Cord Blood KU Leuven Hasselt University
IMPORTANCE: Exposure to ambient air pollution has been associated with the risk of carcinogenesis in later life. Changes in histone modifications might have long-term adverse health effects. OBJECTIVE: To investigate the association of prenatal exposure to ambient air pollution with levels of circulating total histone H3 and specific trimethylation marks (ie, H3 lysine 4, H3 lysine 36) in maternal cord blood. DESIGN, SETTING, AND PARTICIPANTS: ...