Projects
Macrophage activation syndrome in IFN-gamma-deficient mice: key role of natural killer cells and role of defective IFN-gamma signaling. KU Leuven
Where multiple sclerosis strikes: discovery of target antigens involved in MS pathogenicity, with emphasis on molecular mimicry and epitope spreading. University of Antwerp
The role of the innate immune system in the pathogenesis of systemic juvenile idiopathic arthritis: advances in understanding KU Leuven
Systemic juvenile idiopathic arthritis (sJIA) is a severe autoinflammatory childhood-onset immune disorder, classified as one of the JIA subtypes. Patients clinically present with fever, skin rash, enlarged lymph nodes (LNs), spleen and/or liver, and develop arthritis. Haematologically, neutrophilia (including immature neutrophils), leukocytosis, anaemia, and thrombocytosis is noticed. Patients have high plasma cytokine levels of ...
Unraveling metabolic features of microglia and macrophages highlighting the role of peroxisomal β-oxidation KU Leuven
Background
All neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis but also rare inherited metabolic diseases have an inflammatory component (1). Microglia, the immune cells of the brain, are pivotal cells in the generation of this inflammatory response to acute and chronic alterations in brain homeostasis (2). These cells convert from a surveying phenotype in ...