The molecular and structural basis of pro- and anti-inflammatory signalling assemblies mediated by IL-27 and IL-35. Ghent University
Mammalian cellular development and regulation of the immune system crucially depend on appropriate signalling pathways initiated by dedicated cytokine-receptor assemblies at the cellsurface. The downside of such a key physiological activity is that native and mutant forms of cytokines and their receptors are often pivotal to the initiation and progression of inflammatory disorders, cellular malignancies and cancer. Interleukin-35 (IL-35) and ...