Improved data-driven bioinformatics tools to greatly extend neo- and xeno-epitope landscapes detected by immunopeptidomics. Ghent University
Vaccination has proven to be very successful, resulting in the eradication of smallpox and the near-eradication of poliovirus, for example. Currently, vaccination is available for over 29 diseases and is estimated to prevent over 3 million deaths a year. However, for some diseases such as cancer and tuberculosis, effective vaccines are not yet available. A major problem in developing vaccines for diseases such as cancer and those caused by ...
Development of immunoinformatics tools for the discovery of T-cell epitope recognition rules. University of Antwerp
Determining the in vivo role of chronic inflammatory burden through quantification of the GlycA biomarker in a spectrum of inflammatory and immuno-depressed pathologies KU Leuven
A novel biomarker called GlycA is a summary measure for the concentration of specific inflammation-related glycoproteins and the degree to which they are acetylated; hence its name Glycoprotein Acetylation. Previous studies have shown that this biomarker is an excellent summary measure for chronic inflammatory burden: increased GlycA is associated with short term all-cause mortality, cardiovascular disease risk, metabolic syndrome and disease ...
Phase I/II clinical trial on autologous cancer-testis antigen targeted dendritic cell immunotherapy (TriMixDC) for patients with inoperable pretreated colorectal cancer Ghent University
2012-206: Phase I/II clinical trial on autologus cancer-testis antigen targeted dendritic cell immunotherapy (TriMixDC) for patients with inoperable pretreated colorectal cancer
Stichting tegen Kanker
Investigation of predictive baseline tumor characteristics and therapy monitoring for the activity of novel immunotherapies in patients with advanced melanoma Ghent University
Actie 29 van het kankerplan
Investigation of predictive baseline tumor characteristics and therapy monitoring for the
activity of novel immunotherapies in patients with advanced melanoma.
FOD Volksgezondheid via UZ Gent
Applying bioinformatics in dendritic cell-mediated immune cell activation research: automated analysis of high-dimensional flow cytometry datasets. University of Antwerp
Alma-in-Slico: Development of a Euregional Bioinformatics and System Biology Platform for creating, integrating, dissiminating, and exploiting knowledge generated from multi-centre biological data. Hasselt University
Covid-Track: applying quantitative virology and single-cell genomics to unravel the virus-host interactions leading to severe immunopathologies in COVID-19 patients Ghent University
The world is under the spell of SARS-CoV2. More insight is urgently needed into how this new virus disrupts the human immune system and can cause serious illness. In this project we will work with a consortium of clinicians, virologists, immunologists, single-cell experts and bioinformatics scientists
to gain a better understanding of the immunopathology of SARS-CoV2.
Immune-mediated non-communicable diseases are chronic disorders in which the immune system plays a pivotal role, such as autoimmune and allergic diseases(1).
Autoimmune diseases can be divided into at least 100 diseases or syndromes, of which some are organ-specific (e.g. autoimmune thyroid disease) and others are systemic (e.g. systemic sclerosis). Although taken separately these are rare diseases as a whole they affect 7.6–9.4% of the ...