Projects
The role of investment banks in Chinese domestic IPOs KU Leuven
Identification of novel treatment targets through improved pathomechanistic insight in IPO8 deficient aortopathy. University of Antwerp
Functional assessment and therapeutic targeting of a novel aortopathy syndrome caused by resessive IPO8 mutations. University of Antwerp
A Strategic Learning Assessment of ILO Employment Promotion Interventions KU Leuven
This strategic learning assessment aims to improve the design, effectiveness and measurability of ILO employment interventions programmes and projects. It will seek to use and apply latest knowledge available from impactful programmes both within and outside the ILO with the view to sharpen ILO employment projects intervention models and theories of change. The analysis will be based on a detailed review of ILO project evaluations, project ...
IP3 receptor dysregulation as a proximal event in Alzheimer's disease: exploring ans exploiting Bcl-2 proteins. KU Leuven
Alzheimer’s disease, the most frequent form of dementia, which has an enormous impact on quality of life and society. Mutations in presenilins are an important risk factor of developing familial Alzheimer’s disease. At late stages, the disease is characterized by toxic protein aggregates (amyloid beta) and the demise of cells in the brain (neurons) responsible for memory function. While neuronal loss cannot be reverted and lost neurons ...
Targeting dysregulated IP3 receptor-mediated calcium signaling as an early event in Alzheimer’s disease through its Bcl-2-interaction network KU Leuven
Alzheimer’s disease, the most frequent form of dementia, has an enormous impact on the quality of life and society. At late stages, the disease is characterized by toxic protein aggregates (amyloid beta) and the demise of cells in the brain (neurons). While neuronal loss cannot be reverted, it is possible to delay this process. Thus, it is instrumental to focus on the early stages in Alzheimer’s disease development, with one of the key ...
Bcl-2/Bcl-XL proteins as modulators of calcium signaling through IP3 receptors: from novel molecular mechanisms to implications for therapeutics KU Leuven
Physiological significance of pyruvate kinase M2 interaction with the IP3 receptor and its application as a new way to induce apoptosis. KU Leuven
The inositol trisphosphate (IP3) receptor (IP3R) is an intracellular Ca2+-release channel located on the endoplasmic reticulum and responsible for complex Ca2+ signals regulating a variety of intracellular processes including programmed cell death or apoptosis. The IP3R is itself modulated by various intracellular factors including regulatory proteins. Own preliminary results already indicated that pyruvate kinase M2 (PKM2), a metabolic ...
Elucidating novel determinants and mechanisms underlying IP3 receptor regulation by anti-apoptotic Bcl-2-family members KU Leuven
Anti-apoptotic Bcl-2 proteins are fundamental regulators of apoptotic cell death. These proteins have with a major medical relevance, given their upregulation & critical survival role in different cancer cell types. These proteins not only act at the level of mitochondria, the “apoptosis executioner” organelle, but also at the endoplasmic reticulum, the main Ca2+ storage organelle. At the ER, Bcl-2 proteins exert their function by ...