Advancing RNA-based T-cell receptor redirection of lymphocytes to improve antitumor responses in adoptive T-cell immunotherapy for acute myeloid leukemia University of Antwerp
Genetic engineering of T cells for adoptive cell transfer has marked a turning point in personalized immunotherapy, especially in the treatment of cancer. This strategy focuses on specifically targeting tumor-associated antigens (TAAs) by modifying T cells with immune receptors, such as T-cell receptors (TCRs), to improve T-cell ability to detect and eradicate tumor cells. T cells express TCRs that recognize short peptides derived from the ...