Projects
SEvere MAlaria treatment with Rectal artesunate and Artemisinin-based Combination Therapy [in remote settings] (SEMA ReACT). University of Antwerp
Understanding the dissemination of Cryptococcus neoformans and Cryptococcus gattii - a longitudinal in vivo imaging study. KU Leuven
Cryptococcus neoformans and C. gattii are encapsulated yeasts that are opportunistic pathogens, affecting 1 million people/ year, predominantly by inhalation, leading to latent pneumonia. However, the most common and severe presentation is infection of the brain. The traversal of cryptococci across the blood-brain barrier (BBB) is a crucial step in its pathogenesis; but how and when this happens is still enigmatic. Experimental data suggests ...
Deciphering human norovirus cell tropism and pathogenesis using zebrafish KU Leuven
Human noroviruses (HuNoVs) are the most common cause of gastroenteritis, resulting in 219000 deaths/year and a societal cost of $60 billion. The lack of robust small animal models has hindered the understanding of HuNoV biology and the development of effective therapeutics. Our team established the most simple and robust HuNoV replication model available using zebrafish larvae. We will now investigate the unknown details of HuNoV pathogenesis ...
OZR backup mandate: The influence of the gut microbiome on mRNA-based HIV-1 vaccination Vrije Universiteit Brussel
against the virus. This difference is partly due to the fact that HIV is a very variable virus that affects the immune system, which is
supposed to protect us. That is ...
ICP Connect - Master of Epidemiology University of Antwerp
Antimicrobial Resistance, Prescribing, and Consumption Data to Inform Country Antibiotic Guidance and Local Action (ADILA). University of Antwerp
Dynamics of the Type 3 secretion system translocase(DOT3S) KU Leuven
The type III secretion system performs specialized protein export. Its central component is the injectisome, a miniature syringe that sticks out of bacterial cells and jabs eucaryotic membranes. Pathogenic bacteria use it to deliver toxins directly into eukaryotic cells. To control pathogenicity, we need to understand what the injectisome looks like and how it works. For years scientists have tried to do this in living bacteria by removing ...
Investigation of the underlying mechanism by which the PKA and calcineurin pathway regulate stress tolerance in the human fungal pathogen Candida glabrata KU Leuven
Candida glabrata is an opportunistic fungal pathogen that often colonizes the skin and mucosal surfaces of healthy individuals. However, in immunocompromised patients, it can cause diseases leading to blood-stream, oral and vaginal infections and eventually death. A major characteristic of this species is its very high tolerance to a wide number of stresses, including antifungal stress. Its intrinsic tolerance to fluconazole, the most used ...