Organisations
Russinova Lab Flanders Institute for Biotechnology
Laboratory of Protein Phosphorylation and Proteomics KU Leuven
- We investigate the regulation of (patho)physiological processes via reversible protein phosphorylation, and explore the therapeutic potential of the kinases and phosphatases involved. Focus is on Protein Kinase D (PKD) and Protein Phosphatase 2A (PP2A), but increasingly also on broader (kinome and phosphatome wide) approaches to systematically identify kinases/phosphatases that are implicated in (patho)physiological ...
Laboratory of Virology and Chemotherapy (Rega Institute) KU Leuven
This unit designs and develops antiviral and antitumor agents, primarily nucleoside, nucleotide or oligonucleotide analogues but also other substances which interact with enzymes involved in nucleic acid metabolism (i.e. DNA polymerase, reverse transcriptase, thymidine kinase, thymidylate kinase, nucleoside phosphorylase, dihydropyrimidine dehydrogenase, adenosine deaminase, S-adenosylhomocysteine hydrolase, IMP dehydrogenase, OMP ...
Beeckman Lab Flanders Institute for Biotechnology
Dean's Office of the Faculty of Pharmaceutical Sciences Ghent University
Laboratory for Genetics of Malignant Disorders KU Leuven
The discovery and functional characterization of new, recurrent cytogenetic or molecular aberrations in malignant disorders are the most important research objectives of the laboratory for Genetics of Malignant Disorders. These research objectives connect almost seamlessly with the diagnostic, cytogenetic and molecular services which CME-UZ offers for nearly each malignant pathology: acute and chronic leukaemia, lymphomas, mesenchymal and ...
Laboratory of Chemical Biology KU Leuven
The Laboratory of Chemical Biology develops and applies small molecule tools that covalently modify proteins according to a certain trait. We particularly focus on molecules named activity-based probes. These react with active enzymes within a whole proteome and enable a read-out by SDS-PAGE, mass spectrometry, fluorescence spectroscopy or microscopy. Besides probe development, we focus on several protease families including the intramembrane ...
Laboratory of Experimental Oncology KU Leuven
There are five main research topics in the Laboratory of Experimental Oncology ( LEO):
- molecular characterization of rare tumors focused on identification of predictive biomarkers;
- preclinical efficacy studies of novel targeted agents in soft tissue sarcomas using a unique panel of xenograft models derived from patient samples;
- translational research, identifying prognostic markers related to experimental treatment, ...
Laboratory of Molecular and Cellular Signaling KU Leuven
The main focus of the research of the Laboratory of Molecular and Cellular Signaling is Ca2+ signalling in health and disease. We have a longstanding tradition in the investigation of cellular Ca2+ signalling both in single cells and in cell populations. We have developed a number of state-of-the-art techniques including fluorescence and confocal microscopy, luminescence and fluorescence multiplate reader, flux experiments with 45Ca2+ and a ...