Analysis of kynurenines in serum of bipolar patients and their association with affective and cognitive symptoms. University of Antwerp
This project will evaluate the association of an upregulated kynurenine pathway with the clinical symptomatology in bipolar disorder (BD). Therefore, an analytical method based on liquid chromatography-mass spectrometry will be developed for the detection of kynurenines in serum. The method will be applied on samples from BD patients in parallel with mood state monitoring. Project results could aid in a better understanding of BD pathophysiology.