Role of the bone marrow microenvironment in the development of glucocorticoid resistance in lymphoid malignancies Ghent University
Multiple myeloma (MM) is a plasma cell malignancy that is localized in the bone marrow. MM represents 10% of all hematological cancers and approximately 800 patients are diagnosed annually with MM in Belgium. Today, newly diagnosed patients are treated with varying combinations of chemotherapy, proteasome inhibitors, immunomodulatory drugs and glucocorticoids (GCs). As high-Âdose GCs are used in all treatment stages, theyremain the ...