The cellular co-factor LEDGF/p75 determines lentiviral integration sites in the chromosome KU Leuven
BackgroundLentiviruses and the viral vectors derived thereof can insert their viral genome into the chromosome of a non-dividing cell. During this process the viral integrase is assisted by various cellular cofactors. Our group identifies and validates cellular cofactors of nuclear import and integration. LEDGF/p75 was originally identified in our group as a binding partner of HIV-1 integrase and as a chromosomal tether. Data suggest a role for ...